Proteomics

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Proteome characterization of germ cell tumor-related somatic-type malignancies for the identification of tissue origin, cisplatin resistance mechanisms, and putative therapeutic options

ABSTRACT: Germ cell tumors (GCT) can be distinguished into seminoma and non-seminoma. The latter comprises embryonal carcinoma, which can further differentiate into choriocarcinoma, teratoma (TER), and yolk-sac tumors (YST). However, GCT can transform into a somatic-type malignancy (STM), eventually resulting in an unfavorable outcome. This study aimed at enlightening the molecular mechanisms leading to STM formation by comparing them to TER and YST as presumable tissues of origin, thereby paving the way for the identification of novel druggable targets.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Testis

SUBMITTER: Stella Pauls  

LAB HEAD: Kai Stühler

PROVIDER: PXD039546 | Pride | 2024-01-26

REPOSITORIES: Pride

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Characterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor-related somatic-type malignancies to identify the tissue-of-origin, mechanisms of therapy resistance, and druggable targets.

Bremmer Felix F   Pongratanakul Pailin P   Skowron Margaretha M   Che Yue Y   Richter Annika A   Küffer Stefan S   Reuter-Jessen Kirsten K   Bohnenberger Hanibal H   Pauls Stella S   Kresbach Catena C   Schüller Ulrich U   Stühler Kai K   Ströbel Philipp P   Albers Peter P   Nettersheim Daniel D  

British journal of cancer 20230919 10

<h4>Background</h4>Germ cell tumors (GCT) might undergo transformation into a somatic-type malignancy (STM), resulting in a cell fate switch to tumors usually found in somatic tissues, such as rhabdomyosarcomas or adenocarcinomas. STM is associated with a poor prognosis, but the molecular and epigenetic mechanisms triggering STM are still enigmatic, the tissue-of-origin is under debate and biomarkers are lacking.<h4>Methods</h4>To address these questions, we characterized a unique cohort of STM  ...[more]

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