Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Michal Bassani-Sternberg
LAB HEAD: Michal Bassani-Sternberg
PROVIDER: PXD039789 | Pride | 2023-10-24
REPOSITORIES: Pride
Zimmermannova Olga O Ferreira Alexandra G AG Ascic Ervin E Velasco Santiago Marta M Kurochkin Ilia I Hansen Morten M Met Özcan Ö Met Özcan Ö Caiado Inês I Shapiro Ilja E IE Michaux Justine J Humbert Marion M Soto-Cabrera Diego D Benonisson Hreinn H Silvério-Alves Rita R Gomez-Jimenez David D Bernardo Carina C Bauden Monika M Andersson Roland R Höglund Mattias M Miharada Kenichi K Nakamura Yukio Y Hugues Stephanie S Greiff Lennart L Lindstedt Malin M Rosa Fábio F FF Pires Cristiana F CF Bassani-Sternberg Michal M Svane Inge Marie IM Pereira Carlos-Filipe CF
Science immunology 20230707 85
Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 36 cell lines derived from human and mouse hematological and solid tumors. Within 9 days of reprogram ...[more]