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ABCB5+ limbal epithelial stem cells inhibit developmental, but promote inflammatory (lymph)angiogenesis while preventing corneal inflammation

ABSTRACT: ABCB5 is marker for Limbal epithilal stem cells. A comparison between ABCB5+ versus ABCB5- cultured human limbal epithelial cells was carried out to evaluate the properties of the limbal stem cell ABCB5+ with a special focus on their role in inflammation and angiogenesis.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Corneal Epithelium

SUBMITTER: Prerana Wagle

LAB HEAD: Maria Notara

PROVIDER: PXD041004 | Pride | 2023-10-24

REPOSITORIES: Pride

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ABCB5+ Limbal Epithelial Stem Cells Inhibit Developmental but Promote Inflammatory (Lymph) Angiogenesis While Preventing Corneal Inflammation.

Meshko Berbang B Volatier Thomas L A TLA Hadrian Karina K Deng Shuya S Hou Yanhong Y Kluth Mark Andreas MA Ganss Christoph C Frank Markus H MH Frank Natasha Y NY Ksander Bruce B Cursiefen Claus C Notara Maria M

Cells 20230627 13

The limbus, the vascularized junction between the cornea and conjunctiva, is thought to function as a barrier against corneal neovascularization. However, the exact mechanisms regulating this remain unknown. In this study, the limbal epithelial stem cell (LESC) marker ABCB5 was used to investigate the role of LESCs in corneal neovascularization. In an ABCB5KO model, a mild but significant increase of limbal lymphatic and blood vascular network complexity was observed in developing mice (4 weeks) ...[more]

PMID: 37443766

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