Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Cell, Blood
DISEASE(S): Acute Leukemia
SUBMITTER: Ashokkumar Jayavelu
LAB HEAD: Dr.Ashok Kumar Jayavelu
PROVIDER: PXD041245 | Pride | 2024-01-26
REPOSITORIES: Pride
Tubío-Santamaría Nuria N Jayavelu Ashok Kumar AK Schnoeder Tina M TM Eifert Theresa T Hsu Chen-Jen CJ Perner Florian F Zhang Qirui Q Wenge Daniela V DV Hansen Fynn M FM Kirkpatrick Joanna M JM Jyotsana Nidhi N Lane Steven W SW von Eyss Björn B Deshpande Aniruddha J AJ Kühn Michael W M MWM Schwaller Juerg J Cammann Clemens C Seifert Ulrike U Ebstein Frédéric F Krüger Elke E Hochhaus Andreas A Heuser Michael M Ori Alessandro A Mann Matthias M Armstrong Scott A SA Heidel Florian H FH
Molecular cancer 20231204 1
Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance frequently develops to single agents. This points to a need for therapeutic combinations that target multiple mechanisms. To enhance our understanding of functional dependencies in KMT2A-r AML, we have used a proteomic approach to identify the catalytic immunoproteasome subunit PSMB8 as a specific vulnerability. Genetic and ph ...[more]