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Post-transplant diabetes mellitus after kidney transplantation

ABSTRACT: Diabetes mellitus (DM) after transplantation remains a crucial clinical problem in kidney transplantation. To obtain insights into molecular mechanisms underlying the development of post-transplant diabetes mellitus (PTDM) and its early impact on glomerular structures, here we comparatively analyze the proteome of histologically normal appearing glomeruli from patients with PTDM from normoglycemic (NG) transplant recipients, and from recipients with pre-existing type 2 DM (PTDM)

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Kidney

SUBMITTER: Jessica Furriol

LAB HEAD: Hans-Peter Marti

PROVIDER: PXD042188 | Pride | 2023-10-24

REPOSITORIES: Pride

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Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts.

Kipp Anne A Marti Hans-Peter HP Babickova Janka J Nakken Sigrid S Leh Sabine S Halden Thea A S TAS Jenssen Trond T Vikse Bjørn Egil BE Åsberg Anders A Spagnoli Giulio G Furriol Jessica J

BMC nephrology 20230825 1

<h4>Background</h4>Diabetes mellitus (DM), either preexisting or developing after transplantation, remains a crucial clinical problem in kidney transplantation. To obtain insights into the molecular mechanisms underlying PTDM development and early glomerular damage before the development of histologically visible diabetic kidney disease, we comparatively analysed the proteome of histologically normal glomeruli from patients with PTDM and normoglycaemic (NG) transplant recipients. Moreover, to as ...[more]

PMID: 37626301

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