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Effect of Flavivirus infections on host cell gene and protein expression

ABSTRACT: As obligate intracellular parasites, viruses rely heavily on their host cells for their replication, and therefore dysregulate several cellular processes for their benefit. In return, host cells activate multiple signaling pathways to limit viral replication and eradicate viruses. The present study explores the complex interplay between viruses and their host cells through next generation RNA sequencing as well as mass spectrometry (SILAC).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Carolin Brand

LAB HEAD: Martin Bisaillon

PROVIDER: PXD042208 | Pride | 2023-10-24

REPOSITORIES: Pride

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Publications

Kunjin Virus, Zika Virus, and Yellow Fever Virus Infections Have Distinct Effects on the Coding Transcriptome and Proteome of Brain-Derived U87 Cells.

Brand Carolin C Deschamps-Francoeur Gabrielle G Bullard-Feibelman Kristen M KM Scott Michelle S MS Geiss Brian J BJ Bisaillon Martin M

Viruses 20230623 7

As obligate intracellular parasites, viruses rely heavily on host cells for replication, and therefore dysregulate several cellular processes for their benefit. In return, host cells activate multiple signaling pathways to limit viral replication and eradicate viruses. The present study explores the complex interplay between viruses and host cells through next generation RNA sequencing as well as mass spectrometry (SILAC). Both the coding transcriptome and the proteome of human brain-derived U87 ...[more]

PMID: 37515107

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