Patient-based model systems for AD
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Brain
DISEASE(S): Alzheimer's Disease
SUBMITTER: 
Melinda Rezeli
LAB HEAD: Melinda Rezeli
PROVIDER: PXD042229 | Pride | 2023-10-24
REPOSITORIES: Pride
Publications
Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer's disease pathogenesis.
Pomeshchik Yuriy Y Velasquez Erika E Gil Jeovanis J Klementieva Oxana O Gidlöf Ritha R Sydoff Marie M Bagnoli Silvia S Nacmias Benedetta B Sorbi Sandro S Westergren-Thorsson Gunilla G Gouras Gunnar K GK Rezeli Melinda M Roybon Laurent L
Acta neuropathologica communications 20230915 1
The hippocampus is a primary region affected in Alzheimer's disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mechanisms. To address this issue, we examined the cellular origin and progression of AD pathogenesis by comparing patient-based model systems including iPSC-derived brain cells transplanted into the mouse brain hippocampus. Proteomic analysis of the graft enabled the identification of pathways ...[more]
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