Proteomics

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Proteomic analysis identifies proteins related to insulin resistance

ABSTRACT: Illuminating the mechanisms controlling glucose homeostasis may deepen our understanding of the pathogenesis of T2DM and extend our armamentarium of medications for more specific and tailored treatment of T2DM in future. Employing gain-of-function and loss-of-function approaches, we previously established the role of hepatic Dyrk1b in systemic glucose homeostasis and insulin resitance. To analyze the mechnisms for Dyrk1b in regulation of glucose homeostasis and insulin signaling, TMT-based quantitative proteomics were performed in livers of Dyrk1b overexpression mice and control mice. In this study, we identified 599 differentially expressed proteins (DEPs) in Dyrk1b overexpression mice and verified some of them by western blot. Our findings will advance the understanding of the mechanisms of glycemic control and the pathogenesis of T2DM.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Lianju Li  

LAB HEAD: Jiqiu Wang

PROVIDER: PXD042393 | Pride | 2025-05-06

REPOSITORIES: Pride

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Publications

Hepatic Dyrk1b impairs systemic glucose homeostasis by modulating Wbp2 expression in a kinase activity-dependent manner.

Li Lianju L   Zou Yaoyu Y   Shen Chongrong C   Chen Na N   Tong Muye M   Liu Ruixin R   Wang Jiqiu J   Ning Guang G  

Heliyon 20240822 17

Patients with gain-of-function mutations of Dyrk1b have higher fasting blood glucose (FBG) levels. However, the role of Dyrk1b in glucose metabolism is not fully elucidated. Herein, we found that hepatic Dyrk1b overexpression in mice impaired systemic glucose tolerance and hepatic insulin signaling. Dyrk1b overexpression in vitro attenuated insulin signaling in a kinase activity-dependent manner, and its kinase activity was required for its effect on systemic glucose homeostasis and hepatic insu  ...[more]

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