Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Non-small Cell Lung Carcinoma
SUBMITTER: John Koomen
LAB HEAD: José Conejo-Garcia
PROVIDER: PXD042914 | Pride | 2025-05-06
REPOSITORIES: Pride
Action | DRS | |||
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20230119_Conejo-Garcia_2_JChain-Check.raw | Raw | |||
F003736.dat | Other | |||
F003740.dat | Other | |||
IgA_Antibody_Dimer_DDA_HFX.raw | Raw | |||
checksum.txt | Txt |
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Biswas Subir S Mandal Gunjan G Anadon Carmen M CM Chaurio Ricardo A RA Lopez-Bailon Luis U LU Nagy Mate Z MZ Mine Jessica A JA Hänggi Kay K Sprenger Kimberly B KB Innamarato Patrick P Harro Carly M CM Powers John J JJ Johnson Joseph J Fang Bin B Eysha Mostafa M Nan Xiaolin X Li Roger R Perez Bradford A BA Curiel Tyler J TJ Yu Xiaoqing X Rodriguez Paulo C PC Conejo-Garcia Jose R JR
Immunity 20231030 11
Dimeric IgA (dIgA) can move through cells via the IgA/IgM polymeric immunoglobulin receptor (PIGR), which is expressed mainly on mucosal epithelia. Here, we studied the ability of dIgA to target commonly mutated cytoplasmic oncodrivers. Mutation-specific dIgA, but not IgG, neutralized KRAS<sup>G12D</sup> within ovarian carcinoma cells and expelled this oncodriver from tumor cells. dIgA binding changed endosomal trafficking of KRAS<sup>G12D</sup> from accumulation in recycling endosomes to aggreg ...[more]