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LC-MS of Human Blood of Pancreatic neuroendocrine tumors

ABSTRACT: Pancreatic Neuroendocrine tumors are challenging to diagnose and often detected at advanced stages due to lack of specific and sensitive biomarkers. This study utilized proteomics as a valuable approach for cancer biomarker discovery, therefore, mass spectrometry-based proteomic profiling was conducted on plasma samples from 12 subjects (3 controls; 9 PanNET patients) to identify potential proteins capable of effectively distinguish PanNET from healthy controls. 13.2% of proteins were uniquely identified in PanNET, while 60% were commonly expressed in PanNET and controls. 17 proteins exhibiting significant differential expression between PanNET and controls were identified with downstream analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Endocrine Pancreas Disease

SUBMITTER: Priya Kumari Gorai

LAB HEAD: Neerja Rani

PROVIDER: PXD045045 | Pride | 2024-01-26

REPOSITORIES: Pride

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			Action	DRS
	C4_rep1.raw	Raw
	C4_rep2.raw	Raw
	C5_rep1.raw	Raw
	C5_rep2.raw	Raw
	C6_rep1.raw	Raw

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Publications

C1QA and COMP: plasma-based biomarkers for early diagnosis of pancreatic neuroendocrine tumors.

Gorai Priya Kumari PK Bharti Prahalad Singh PS Kumar Shashi S Rajacharya Girish H GH Bandyopadhyay Sabyasachi S Pal Sujoy S Dhingra Renu R Kumar Rakesh R Nikolajeff Fredrik F Kumar Saroj S Rani Neerja N

Scientific reports 20231129 1

Pancreatic Neuroendocrine tumors (PanNET) are challenging to diagnose and often detected at advanced stages due to a lack of specific and sensitive biomarkers. This study utilized proteomics as a valuable approach for cancer biomarker discovery; therefore, mass spectrometry-based proteomic profiling was conducted on plasma samples from 12 subjects (3 controls; 5 Grade I, 4 Grade II PanNET patients) to identify potential proteins capable of effectively distinguishing PanNET from healthy controls. ...[more]

PMID: 38030709

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