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Parabiosis Suppresses Breast Tumor Growth With Increased Effector Memory T Cells and HSPB3

ABSTRACT: To evaluate anti-tumor effects of parabiosis followed by breast tumor cells re-challenge, breast tumor cells were injected to fourth mammary gland in one mouse of parabiosis mice. After 28 days, tumor cells were re-challenged to the other mice without tumor from separated parabiosis mice (Separant-tumor), and tumor growth was observed for 14 days. As positive control as only tumor cells injected mice (Tumor) and naïve mice (Naïve) as negative control were used. To screen out candidates of anti-tumor protein in serum of mice, liquid chromatography–mass spectrometry (LC-MS) was performed.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Serum

SUBMITTER: Kyu-hyun Han

LAB HEAD: Dong-ik Kim

PROVIDER: PXD045474 | Pride | 2026-08-04

REPOSITORIES: Pride

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			Action	DRS
	20220530_SAMSUNG_H.pdStudy	Other
	20220530_SAMSUNG_H_N6.raw	Raw
	20220530_SAMSUNG_H_N8.raw	Raw
	20220530_SAMSUNG_H_P5.raw	Raw
	20220530_SAMSUNG_H_P7.raw	Raw

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Publications

Parabiosis Suppresses Breast Tumor Growth With Increased Effector Memory T Cells and HSPB3.

Han Kyu-Hyun KH Kim Ae-Kyeong AK Bhang Suk Ho SH Kim Dong-Ik DI

Anticancer research 20260801 8

<h4>Background/aim</h4>Parabiosis, a model involving shared circulation between two organisms, enables the investigation of systemic immune factors in tumor biology. This study aimed to evaluate whether breast tumor growth is suppressed in naïve mice following parabiosis with tumor-bearing mice and to identify associated immune cell changes and circulating anti-tumor factors.<h4>Materials and methods</h4>Parabiosis was established between breast tumor-bearing mice and naïve mice. After 28 days, ...[more]

PMID: 42527102

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