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Immune cell proteomes of Long COVID patients have functional changes similar to those in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

ABSTRACT: To investigate the pathophysiology of Long COVID (LC), a pilot study of patients and healthy controls has used quantitative proteomics to discover changes in peripheral blood mononuclear cell (PBMC) proteoms. The proteomes of LC patients and healthy controls were analysed by Sequential Window Acquisition of all Theoretical Fragment Ion Spectra-Mass Spectrometry (SWATH-MS).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Peripheral Blood Mononuclear Cell, Blood

DISEASE(S): Long Covid

SUBMITTER: Torsten Kleffmann

LAB HEAD: Warren P. Tate

PROVIDER: PXD045508 | Pride | 2025-08-05

REPOSITORIES: Pride

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			Action	DRS
	21074_E1_Lib_RunAFr1.mzML	Mzml
	21074_E1_Lib_RunAFr10.mzML	Mzml
	21074_E1_Lib_RunAFr11.mzML	Mzml
	21074_E1_Lib_RunAFr2.mzML	Mzml
	21074_E1_Lib_RunAFr3.mzML	Mzml

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A pilot study on the immune cell proteome of long COVID patients shows changes to physiological pathways similar to those in myalgic encephalomyelitis/chronic fatigue syndrome.

Peppercorn Katie K Edgar Christina D CD Kleffmann Torsten T Tate Warren P WP

Scientific reports 20231212 1

Of those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ~ 10% develop the chronic post-viral debilitating condition, long COVID (LC). Although LC is a heterogeneous condition, about half of cases have typical post-viral fatigue with onset and symptoms that are very similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A key question is whether these conditions are closely related. ME/CFS is a post-stressor fatigue condition that arises from multiple ...[more]

PMID: 38086949

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