Dataset Information

Proteomic changes in lens of diabetic, age-related and post-vitrectomy cataract.

ABSTRACT: The focus of our research centers on exploring the proteome changes and corresponding signaling pathways involved in the development of diabetic cataract, age-related cataract and post-vitrectomy cataract, investigating aqueous humor, anterior capsule and lens human samples. Outstanding proteomic profiles of the three sample types have been generated using DIA proteomics. We have observed substantial differences in the regulation of several pathways between our groups and samples types, and we have particularly highlighted the involvement of non-canonical Wnt receptor signaling pathway, glycosaminoglycan and glycosphingolipid pathways, and oxidation reduction pathway in the formation of different cataract forms.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lens

DISEASE(S): Cataract

SUBMITTER: Martina Samiotaki

LAB HEAD: Christina Karakosta

PROVIDER: PXD045557 | Pride | 2025-05-06

REPOSITORIES: Pride

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Publications

Proteomic Changes of Glycolipid Pathways in Age-Related, Diabetic, and Post-Vitrectomy Cataracts.

Karakosta Christina C Samiotaki Martina M Panayotou George G Papaconstantinou Dimitrios D Moschos Marilita M MM

Journal of clinical medicine 20241130 23

<b>Background</b>: Alterations in glycolipid and glycosphingolipid pathways lead to compromised cell membranes and may be involved in cataract formation. However, the exact role of glycolipids in lens opacification is not completely understood. The aim of the current study is to investigate proteome complexity and the role of glycolipid and glycosphingolipid pathways in cataract formation. <b>Methods</b>: The anterior capsule and phacoemulsification (phaco) cassette contents were collected durin ...[more]

PMID: 39685745

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