Dataset Information

Potential proteins interated with CHRONO in human U2OS cells

ABSTRACT: We screened the protein partners that associate with CHRONO using immunoprecipitation followed with mass spectrometry (IP-MS). IP-MS identified proteins involved in multiple protein-protein interaction networks that are functional in multiple pathways and cellular functions.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Qin Zhou

LAB HEAD: Ximing Qin

PROVIDER: PXD046945 | Pride | 2025-05-06

REPOSITORIES: Pride

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Publications

The nuclear transportation of CHRONO regulates the circadian rhythm.

Zhou Qin Q Su Yunxia Y Wang Ruohan R Song Zhiyuan Z Ge Honghua H Qin Ximing X

The Journal of biological chemistry 20241024 12

The pace of the endogenous circadian clock is important for organisms to maintain homeostasis. CHRONO has been shown to be a core component of the mammalian clock and has recently been implicated to function in several important physiological aspects. To function properly, CHRONO needs to enter the nucleus to repress transcription. We have previously shown that the N terminus of CHRONO is required for its nuclear entry. However, how CHRONO enters the nucleus and regulates the circadian clock rem ...[more]

PMID: 39454958

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			Action	DRS
	IP_1.raw	Raw
	IP_1.txt	Txt
	IP_2.raw	Raw
	IP_2.txt	Txt
	IgG_1.raw	Raw