Proteomics

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Comprehensive ubiquitomics characterization identify biomarkers of liver cancer subtypes

ABSTRACT: Hepatocellular carcinoma (HCC) has been widely studied at multi-omics level, but little is known about its specific ubiquitination, a major post-translational modification (PTM). In this study, we performed the ubiquitomics data collected from 85 HCC tumors and 18 adjacent normal tissues (ANTs) to establish the ubiquitomic profiles of HCC and reveal tumor-associated characteristics with prognosis and clinical outcomes. Ubiquitomic based stratification of HCC revealed three subtypes related to different clinical and molecular features, suggesting ubiquitomics have the potential to further understand the relationship between ubiquitination levels of proteins and different molecular and clinical features of HCC patients. XAD1—XAD18 --- HCC adjacent normal tissues XC1—XC85--- HCC tumor tissues

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: Chuanming Xie  

LAB HEAD: Chuanming Xie

PROVIDER: PXD047211 | Pride | 2025-04-07

REPOSITORIES: Pride

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Publications

Integrated ubiquitomics characterization of hepatocellular carcinomas.

Lin Xiao-Tong XT   Luo Yuan-Deng YD   Mao Cui C   Gong Yi Y   Hou Yu Y   Zhang Lei-Da LD   Gu Yong-Peng YP   Wu Di D   Zhang Jie J   Zhang Yu-Jun YJ   Tan De-Hong DH   Xie Chuan-Ming CM  

Hepatology (Baltimore, Md.) 20240930 1

<h4>Background and aims</h4>Patients with aggressive HCC have limited therapeutic options. Therefore, a better understanding of HCC pathogenesis is needed to improve treatment. Genomic studies of HCC have improved our understanding of cancer biology. However, the ubiquitomic characteristics of HCC remain poorly understood. We aimed to reveal the ubiquitomic characteristics of HCC and provide clinical feature biomarkers of the aggressive HCC that may be used for diagnosis or therapy in the clinic  ...[more]

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