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Comprehensive chromatome profiling identifies metabolic enzymes on chromatin in healthy and cancer cells

ABSTRACT: we have performed a subcellular fractionation protocol, which enriches the chromatin-bound proteins across a panel of tissue types, both for cancerous and untransformed cells. Indeed we identify both metabolic enzymes which are consistently moonlighting on chromatin, while others are tissue and cancer specific. By comparing the chromatin levels of proteins with their essentiality, we identify enzymes which perform essential functions on chromatin and thus could represent cancer specific metabolic vulnerabilities.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Lung, Colon, Blood

SUBMITTER: Savvas Kourtis

LAB HEAD: Sara Sdelci

PROVIDER: PXD047504 | Pride | 2025-11-13

REPOSITORIES: Pride

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			Action	DRS
	M1045_chrom.zip	Other
	M1046_chrom.zip	Other
	M1047_chrom.zip	Other
	report.tsv	Tabular
	sample_annoation_MS.csv	Csv

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