Project title: Endogenous AIRE-immunoprecipitation from primary human neutrophils

ABSTRACT: Autoimmune regulator (AIRE) is a transcriptional regulator. We here assess the role for AIRE in primary human neutrophils. We found that the functional role for AIRE in neutrophils is to regulate the extrinsic apoptotic pathway involving the Fas/TNFR death receptors and Cathepsin G and the expression of unique immune mediators.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Neutrophil

DISEASE(S): Breast Cancer

SUBMITTER: Charlotte Welinder  

LAB HEAD: Karin Leandersson

PROVIDER: PXD047989 | Pride | 2024-01-25

REPOSITORIES: Pride