Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Neutrophil
DISEASE(S): Breast Cancer
SUBMITTER: Charlotte Welinder
LAB HEAD: Karin Leandersson
PROVIDER: PXD047989 | Pride | 2024-01-25
REPOSITORIES: Pride
Källberg Eva E Mehmeti-Ajradini Meliha M Björk Gunnarsdottir Frida F Göransson Marcus M Bergenfelz Caroline C Allaoui Fredriksson Roni R Hagerling Catharina C Johansson Martin E ME Welinder Charlotte C Jirström Karin K Leandersson Karin K
Journal of leukocyte biology 20240301 4
The autoimmune regulator (AIRE) is a transcriptional regulator expressed in the thymus and is necessary for maintaining immunological self-tolerance. Extrathymic AIRE expression is rare, and a role for AIRE in tumor-associated innate immune cells has not yet been established. In this study, we show that AIRE is expressed in human pro-tumor neutrophils. In breast cancer, AIRE was primarily located to tumor-associated neutrophils (TANs), and to a lesser extent to tumor-associated macrophages (TAMs ...[more]