Proteomics

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Identify the protein contents within the fluids secreted by transplanted human vascularized lung organoid


ABSTRACT: We recently established a hPSC-derived 3D organoid system to mimic the vascularization process during lung differentiation. To further mature the organoid, we embedded them into the mouse kidney capsule for three months and observed the accumulation of fluid within the growing organoids. Therefore, we aim to understand if there are any proteins related to lung function are being secreted in this case.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Minzhe Guo  

LAB HEAD: Mingxia Gu

PROVIDER: PXD048316 | Pride | 2025-07-06

REPOSITORIES: Pride

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Publications


The vasculature and mesenchyme exhibit distinct organ-specific characteristics adapted to local physiological needs, shaped by microenvironmental and cell-cell interactions from early development. To recapitulate this entire process, we co-differentiated mesoderm and endoderm within the same spheroid to vascularize lung and intestinal organoids from induced pluripotent stem cells (iPSCs). Bone morphogenetic protein (BMP) signaling fine-tuned the endoderm-to-mesoderm ratio, a critical step in gen  ...[more]

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