Proteomics

Dataset Information

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Comparative proteomic analysis of the hemolymph and salivary glands of Rhodnius prolixus and R. colombiensis reveals candidates associated with differential lytic activity against Trypanosoma cruzi Dm28c and T. cruzi Y


ABSTRACT: Some factors can facilitate or prevent T. cruzi transmission, i.e. vector immunity. Our work has managed to detect a stronger immune response against T. cruzi II in R. prolixus saliva and haemolymph, compared to that of R. colombiensis. Proteins from both species’ saliva and haemolymph were analysed for studying factors which might have been involved in such response; most proteins were detected in both species’ haemolymph, thereby indicating common immune mechanisms. Three proteins having oxidative immune activity were only expressed in R. prolixus. Lipocalin diversity and abundance predominated in R. prolixus saliva; these proteins are involved in nitric oxide metabolism and their role in immunity could be key in host defence against T. cruzi. Recognising the components modulating parasite transmission in a vector helps in understanding how such factors act independently and how they would act synergistically against T. cruzi, thereby enabling us to establish tools regarding Chaga’s disease epidemiology, aimed at predicting T. cruzi distribution and creating transmission control mechanisms.

INSTRUMENT(S): 4700 Proteomics Analyzer

ORGANISM(S): Rhodnius Colombiensis Rhodnius Prolixus (triatomid Bug)

TISSUE(S): Hemolymph, Saliva

SUBMITTER: Hamilton Barbosa  

LAB HEAD: Hamilton Julian

PROVIDER: PXD048605 | Pride | 2024-03-14

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
23622_1_R_prolixus_hemolymph.zip Other
23624_3_R_colombiensis_hemolymph.zip Other
23627_6_R_prolixus_gland_epithelium.zip Other
23629_8_R_colombiensis_gland_epithelium.zip Other
24331_Prolixus_Hemolymph.zip Other
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