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Quantitative Proteomics of the kidney AKT-mediated response to a potassium-deficient diet

ABSTRACT: Three groups of wild-type mice were fed either a normal diet, a potassium-deficient diet, or a potassium-deficient diet while being co-treated with the AKT inhibitor MK2206 (50 mg/kg). After treatment (4 days), animals were euthanized, and kidneys were snap-frozen in liquid nitrogen.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

SUBMITTER: Kristie Lindsey Rose

LAB HEAD: Kristie Lindsey Rose

PROVIDER: PXD050107 | Pride | 2025-10-27

REPOSITORIES: Pride

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	6276_20230710_totalproteome_mq_evidence.txt	Txt
	6276_20230710_totalproteome_mq_msstats4.4.1_report.xlsx	Xlsx
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Publications

Kir5.1-modulated potassium flux stimulates an anabolic kidney phenotype.

Wu Aihua A Inoue Masa-Ki MK Zhang Yahua Y Hasenour Clinton M CM Arroyo Juan Pablo JP Bock Fabian F Yu Alina A Ferdaus Mohammed Z MZ Blackwell Yvette Y Lazarenko Roman M RM Young Jamey D JD Denton Jerod S JS Delpire Eric E Zhang Ming-Zhi MZ Harris Raymond C RC Terker Andrew S AS

iScience 20250919 10

The kidney maintains systemic potassium (K+) balance through energy-intensive epithelial transport processes. Under K+-restricted conditions, kidney epithelial cells proliferate to accommodate profound increases in transport. Tissue reorganization to minimize systemic K+ loss is essential for survival, yet metabolic details remain obscure. Here, we demonstrate that the most-activated kidney pathways under low K+ conditions are those governing metabolis ...[more]

PMID: 41111916

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