Dataset Information
Effect of Dhps deletion and Citrobacter rodentium on the proteome of colonic epithelial cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Colonic Epithelial Cell, Colon Epithelial Cell
DISEASE(S): Bacterial Infectious Disease,Colitis
SUBMITTER: 
Kristie Lindsey Rose
LAB HEAD: Kristie Lindsey Rose
PROVIDER: PXD051536 | Pride | 2025-05-06
REPOSITORIES: Pride
Dataset's files
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Publications
Hypusination in intestinal epithelial cells protects mice from infectious colitis.
Gut microbes 20240101 1
Enteropathogenic <i>Escherichia coli</i> (EPEC) is a bacterium that causes attaching/effacing (A/E) lesions and serious diarrheal disease, a major health issue in developing countries. EPEC pathogenicity results from the effect of virulence factors and dysregulation of host responses. Polyamines, including spermidine, play a major role in intestinal homeostasis. Spermidine is the substrate for deoxyhypusine synthase (DHPS), which catalyzes the conjugation of the amino acid hypusine to eukaryotic ...[more]
