Hypoxia promotes the generation of a versican-rich extracellular matrix by human coronary artery endothelial cells

ABSTRACT: • Exposure of endothelial cells (HCAECs) to hypoxia alters gene an protein expression • Genes and proteins related to endothelial dysfunction and activation are overexpressed • Hypoxia induces a versican-rich matrix with an altered glycosaminoglycan profile • This modified matrix perturbs cell adhesion but enhances proliferation and hyaluronan binding • Hypoxia upregulates oxidant formation and proteins related to inflammation

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Endothelial Cell Of Artery

SUBMITTER: Lasse Gøbel Lorentzen  

LAB HEAD: Michael Davies

PROVIDER: PXD052078 | Pride | 2025-08-25

REPOSITORIES: Pride