Proteomics

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Proteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia

ABSTRACT: Myopia is a growing global public health concern. The retinal–choroid–sclera (RCS) signalling cascade is crucial in regulating eye growth and is influenced by visually induced signalling. Understanding the molecular mechanisms underlying this cascade is vital to identify therapeutic targets for myopia. This study provides an in-depth proteomic and phosphoproteomic atlas of the RCS in guinea pigs with FDM, uncovering the potential molecular mechanisms driving the progression of myopia.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Choroid, Retina, Sclera

SUBMITTER: Yifan Song  

LAB HEAD: Hongsheng Bi

PROVIDER: PXD052167 | Pride | 2025-11-17

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
XA03515DA_FDM5625_S_B2_1_23732.d.zip Other
XA03515DA_FDM5652_S_B2_1_23733.d.zip Other
XA03515DA_FDM5658_S_B2_1_23731.d.zip Other
XA03515DA_NC5626_S_B1_1_23728.d.zip Other
XA03515DA_NC5628_S_B1_1_23727.d.zip Other
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Publications

Proteomic and Phosphoproteomic Characteristics of the Retina, Choroid, and Sclera in Guinea Pigs with Form-Deprivation Myopia.

Song Yifan Y   Xu Zhe Z   Li Hong-Tao HT   Xie Yunxiao Y   Zhao Lianghui L   Feng Jiaojiao J   Luo Anfeng A   Dai Jiajing J   Li Jing J   Guo Xinran X   Song Jike J   Bi Hongsheng H  

Molecular & cellular proteomics : MCP 20250919 11

Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes (BPs) in the retina, choroid, and sclera is crucial for understanding the molecular mechanisms underlying myopia development. We conducted comprehensive proteomic and phosphoproteomic analyses of the retina, choroid, an  ...[more]

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