Proteomics

Dataset Information

0

Proteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia


ABSTRACT: Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, choroid, and sclera is crucial for understanding the molecular mechanisms underlying myopia development. This study provides an in-depth proteomic and phosphoproteomic atlas of the retina, choroid, and sclera in guinea pigs with form-deprivation myopia, uncovering the potential molecular mechanisms driving the progression of myopia.

INSTRUMENT(S):

ORGANISM(S): Cavia Porcellus (guinea Pig)

TISSUE(S): Sclera

SUBMITTER: Yifan Song  

LAB HEAD: Hongsheng Bi

PROVIDER: PXD067756 | Pride | 2025-11-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Result-R1.zip Other
XA03515DAR1_FDM5625_G_B4_1_23740.d.zip Other
XA03515DAR1_FDM5652_G_B4_1_23741.d.zip Other
XA03515DAR1_FDM5658_G_B4_1_23739.d.zip Other
XA03515DAR1_NC5626_G_B3_1_23736.d.zip Other
Items per page:
1 - 5 of 15
altmetric image

Publications

Proteomic and Phosphoproteomic Characteristics of the Retina, Choroid, and Sclera in Guinea Pigs with Form-Deprivation Myopia.

Song Yifan Y   Xu Zhe Z   Li Hong-Tao HT   Xie Yunxiao Y   Zhao Lianghui L   Feng Jiaojiao J   Luo Anfeng A   Dai Jiajing J   Li Jing J   Guo Xinran X   Song Jike J   Bi Hongsheng H  

Molecular & cellular proteomics : MCP 20250919 11


Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes (BPs) in the retina, choroid, and sclera is crucial for understanding the molecular mechanisms underlying myopia development. We conducted comprehensive proteomic and phosphoproteomic analyses of the retina, choroid, an  ...[more]

Similar Datasets

2025-11-17 | PXD067446 | Pride
2025-11-17 | PXD067757 | Pride
2025-11-17 | PXD052167 | Pride
2019-05-29 | GSE131831 | GEO
2017-02-09 | GSE84220 | GEO
2011-03-22 | E-GEOD-28056 | biostudies-arrayexpress
2008-04-10 | GSE10934 | GEO
2011-03-22 | GSE28056 | GEO
2023-12-20 | GSE227724 | GEO
2022-08-05 | GSE210099 | GEO