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Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs

ABSTRACT: To compare the cardiac mitochondrial proteome of adult, lean Ossabaw minipigs with that of adult, lean Göttingen minipigs

INSTRUMENT(S):

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Heart

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Laxmikanth Kollipara

LAB HEAD: Prof. Dr.

PROVIDER: PXD052197 | Pride | 2026-02-21

REPOSITORIES: Pride

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Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs.

Eickelmann Chantal C Gedik Nilgün N Lieder Helmut Raphael HR Kollipara Laxmikanth L Sickmann Albert A Sturek Michael M Heusch Gerd G Kleinbongard Petra P

American journal of physiology. Heart and circulatory physiology 20260204

Ossabaw minipigs differ from other (mini)pig strains by their genetic predisposition to develop full metabolic syndrome and their non-responsiveness to cardioprotective interventions, even before developing the diseased phenotype. Previous DNA sequencing data revealed differences in a cluster of mitochondrial protein-coding genes between Ossabaw and Göttingen minipigs - a large animal model without such a genetic predisposition and a responsiveness to cardioprotection. Alterations in mitochondri ...[more]

PMID: 41638602

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