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Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs

ABSTRACT: To compare the cardiac mitochondrial proteome of adult, lean Ossabaw minipigs with that of adult, lean Göttingen minipigs

INSTRUMENT(S):

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Heart

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Laxmikanth Kollipara

LAB HEAD: Prof. Dr.

PROVIDER: PXD052197 | Pride | 2026-02-21

REPOSITORIES: pride

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Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs.

Eickelmann Chantal C Gedik Nilgün N Lieder Helmut Raphael HR Kollipara Laxmikanth L Sickmann Albert A Sturek Michael M Heusch Gerd G Kleinbongard Petra P

American journal of physiology. Heart and circulatory physiology 20260204 3

Ossabaw minipigs differ from other (mini)pig strains by their genetic predisposition to develop full metabolic syndrome and their nonresponsiveness to cardioprotective interventions, even before developing the diseased phenotype. Previous DNA sequencing data revealed differences in a cluster of mitochondrial protein-coding genes between Ossabaw and Göttingen minipigs-a large animal model without such a genetic predisposition and a responsiveness to cardioprotection. Alterations in mitochondrial ...[more]

PMID: 41638602

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