Dataset Information

Proteomics and metabolomics profiles of unvaccinated nonagenarian patients with severe SARS-CoV-2 infection

ABSTRACT: The emergence of the coronavirus, SARS-CoV-2, in late 2019 led to a global pandemic with millions of confirmed cases and fatalities. The mortality rate rises significantly in patients over 90 years old; however, there are cases of older adults who survived or were not even infected despite being exposed. In this context, we aim to analyze the plasma proteomic and metabolomic profiles of nonagenarian patients who recovered (Group R) or died (Group D) from severe COVID-19 and compare them with non-infected control subjects (Group C). Plasma samples from the deceased group were collected days before the patients died, whereas plasma from survivors and non-infected individuals exposed to SARS-CoV-2 was collected 1-3 months after the reported infection or exposure. When compared to the control group, non-survivors showed a reduced abundance of specific lipid-related proteins and metabolites, including APOH, APOC1, LCAT, 7-α-25-dihydroxycholesterol, 7-dehydrocholesterol, and phosphatidylethanolamine which may serve as indicative markers of severity. These patients also exhibited elevated levels of N-heterocyclic compounds, potentially indicating an antiviral response. Recovered patients showed minimal differences compared to healthy non-infected subjects, indicating restoration of disrupted metabolic and proteomic profiles. However, proteins associated with acute phase response and complement activation did not return to normal levels. Also, specific metabolites, such as sphingolipids and phospholipids, remain altered in survival nonagenarians even after recovery, indicating persistent effects of COVID-19 infection. Alterations in proteins associated with neuronal function indicate possible brain damage and long-term neurological effects of COVID-19 infection.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Proteomics Unit

LAB HEAD: Fábio César Sousa Nogueira

PROVIDER: PXD052222 | Pride | 2025-11-17

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20210604_COVID_idosos_post_1.cdResult	Other
	20210609_COVID_idosos_neg.cdResult	Other
	20210628_COVID_idosos_4_iRT_4.pdResult	Other
	Am13_01_Neg.raw	Raw
	Am13_01_POS.raw	Raw

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Proteomics and Metabolomics Profiles of Unvaccinated Nonagenarian Patients with Severe SARS-CoV-2 Infection.

Quiñones-Vega Mauricio M Sosa-Acosta Patricia P Guedes Jéssica de Siqueira JS Pinto de Almeida Natália N V de Castro Mateus M Silva Moníze V R MVR Dell'Aquila Luiz P LP Razuk-Filho Álvaro Á Batista-Júnior Pedro B PB Zatz Mayana M Nogueira Fábio César Sousa FCS Domont Gilberto Barbosa GB

Journal of proteome research 20250925 11

The mortality rate of COVID-19 increases significantly in patients over the age of 90, although some elderly people in this category have experienced mild disease or have been asymptomatic. In this context, we aim to analyze the plasma proteomic and metabolomic profiles of unvaccinated nonagenarian patients who had severe manifestations of COVID-19 and either recovered or died and compare them with noninfected control subjects. Compared with healthy individuals, nonsurviving patients showed a re ...[more]

PMID: 40997940

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