Dataset Information

C57BL/6J mouse ovary,4DLabelfree quantitative protein sets from 6 mouse ovarian tissue samples (2 groups, 3 replicates)

ABSTRACT: The ovarian tissues of 3 mice aged 3 months in the control group and the hyperhomocysteinemia group were selected for advanced 4D Laber-free quantitative proteomic analysis. According to 4D Laber-free quantitative proteomics analysis, we successfully quantified 56,611 peptides and identified 5,764 quantifiable proteins. Principal component analysis (PCA) highlights the extraordinary quantitative repeatability between biological replicas. Subsequently, we screened for differentially expressed proteins (DEPs) (P <0.05, multiple change (FC) >1.5). The results showed that there were 317 up-regulated and 113 down-regulated proteins.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Ovary

DISEASE(S): Hyperhomocysteinemia

SUBMITTER: Lu Wang

LAB HEAD: Rong Hu

PROVIDER: PXD053081 | Pride | 2025-05-07

REPOSITORIES: Pride

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Publications

Effects of hyperhomocysteinemia on follicular development and oocytes quality.

Wang Lu L Gao Jinmei J Ma Jie J Sun Jing J Wang Yajie Y Luo Jia J Wang Zhaoyang Z Wang Hui H Li Jialing J Yang Danyu D Wang Jinfang J Hu Rong R

iScience 20241023 11

In patients with polycystic ovary syndrome (PCOS), the concentration of homocysteine (Hcy) in follicular fluid is inversely correlated with oocyte and embryo quality. Nevertheless, other metabolic abnormalities associated with PCOS may also impact oocyte and early embryo quality. Therefore, it remains uncertain whether reproductive function is affected in patients without PCOS with hyperhomocysteinemia (HHcy). Here, we observed reduced fertility, increased ovarian atretic follicles, and reduced ...[more]

PMID: 39563894

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