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4D-DIA of hippocampus in young old and FMT mice

ABSTRACT: To testify how aged gut microbiota regulates the molecular phenotype of the brain, we analyzed mouse hippocampal proteome profile

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Epithelial Cell

DISEASE(S): Cognitive Disorder

SUBMITTER: mingxiao Li

LAB HEAD: houkai li

PROVIDER: PXD053778 | Pride | 2025-07-21

REPOSITORIES: Pride

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			Action	DRS
	XA05845DAR1_A1.raw	Raw
	XA05845DAR1_A2.raw	Raw
	XA05845DAR1_A3.raw	Raw
	XA05845DAR1_B1.raw	Raw
	XA05845DAR1_B2.raw	Raw

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1 - 5 of 11

Publications

Aged Gut Microbiota Contributes to Cognitive Impairment and Hippocampal Synapse Loss in Mice.

Li Mingxiao M Ren Jiaoqi J Bao Yiyang Y Wei Wenjing W Yu Xuefei X He Xiaofang X Gulisima Mutalifu M Sheng Lili L Zheng Ningning N Wan Jianbo J Zhou Houguang H Zhao Ling L Li Houkai H

Aging cell 20250412 7

Gut microbiota alteration during the aging process serves as a causative factor for aging-related cognitive decline, which is characterized by the early hallmark, hippocampal synaptic loss. However, the impact and mechanistic role of gut microbiota in hippocampal synapse loss during aging remains unclear. Here, we observed that the fecal microbiota of naturally aged mice successfully transferred cognitive impairment and hippocampal synapse loss to young recipients. Multi-omics analysis revealed ...[more]

PMID: 40219707

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