Dataset Information

Control Of Major Bleeding After Trauma (COMBAT) Clinical Research Trial

ABSTRACT: Denver Health has conducted the Control of Major Bleeding After Trauma (COMBAT) clinical research study, which aimed to improve trauma care for all patients (https://www.denverhealth.org/services/trauma/for-professionals-2/research-publications/combattrial). The study began in April 2014 and concluded in March of 2017. In collaboration with the University of Colorado Anschutz Medical Campus, longitudinal plasma samples collected from the COMBAT trial were analyzed by MS-based proteomics and metabolomics (available on Metabolomics Workbench).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Ian LaCroix

LAB HEAD: Kirk Hansen

PROVIDER: PXD053799 | Pride | 2025-08-25

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20201202_152106_COMBAT.sne	Other
	COMBAT_Proteomics_DIA_Files_1-200.zip	Other
	COMBAT_Proteomics_DIA_Files_201-401.zip	Other
	COMBAT_Proteomics_DIA_Files_402-602.zip	Other
	COMBAT_Proteomics_DIA_Files_603-814.zip	Other

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1 - 5 of 5

Publications

Trauma-induced dysfibrinogenemia: the von Clauss assay does not accurately measure fibrinogen levels after injury.

DeBot Margot M Erickson Christopher C Schaid Terry T LaCroix Ian I Moore Ernest E EE Silliman Christopher C Cohen Mitchell J MJ D'Alessandro Angelo A Hansen Kirk C KC

Blood vessels, thrombosis & hemostasis 20240716 3

Trauma patients who sustain severe tissue injury and hemorrhage often receive fibrinogen repletion to avert coagulopathy and achieve hemostasis. However, fibrinogen supplementation has not shown a benefit in trauma patients with coagulopathy. The von Clauss functional fibrinogen assay is the primary indication for fibrinogen transfusion. This assay, however, infers fibrinogen levels optically via in vitro clot formation time and does not directly measure the quantity or quality of plasma fibrino ...[more]

PMID: 40766812

Publication: 1/3

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Project description:The study was aimed to identify mechanisms linked to complicated courses after severe trauma by a systems biology approach. In severe trauma, overwhelming systemic inflammation can result in adverse events and the development of complications, including sepsis. In a prospective study, RNA samples from circulating leukocytes from patients with multiple injury (injury severity score â¥ 17) were analyzed for dynamic changes in gene expression over a period of 21 days by whole genome screening. Based on their clinical presentation, patients were divided into two subgroups: patients with secondary sepsis after trauma (n=5) and patients with systemic inflammation without infection (n=5). Expression cluster were defined by correlating gene expression data with clinical outcome parameters. Using unsupervised clustering, patients with systemic inflammation only and patients with sepsis showed a distinct expression pattern and the discrimination of clinical presentation was reflected by clustering of the samples. Explorative gene set analysis revealed robust upregulation of genes related to âhemoglobin metabolism/oxygen transportâ and âpathogenic E.coli infectionâ. 10 patients with multi-system trauma (ISS â¥ 17 points) admitted to the Division of Trauma Surgery at the University Hospital Zurich were included. Whole blood from trauma patients was collected within the first 6 h after trauma (day 0) and on days 1, 2, 3, 5, 7, 10, 14, and 21. Total cellular RNA from circulating leukocytes was isolated using PaxGene Blood RNA Kit (PreAnalytix) for transcriptome profiling. RNA from blood of trauma patients was extracted and subjected to microarray analysis for comparison of longitudinal transcriptomic responses of patients. RNA samples of circulating leukocytes covering time points directly after admission (D0) and on the consecutive days (D1-D21) were subject to multifactorial microarray data analysis: Differences in dynamics of transcripts were assessed by contrasting time- and individual-resolved changes for sepsis and systemic inflammation without infection.