Proteomics

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Multiple classes of antigen contribute to the antigenic landscape of mesothelioma

ABSTRACT: Mesothelioma is an incurable, asbestos-exposure related cancer that typically affects the lining or pleura of the lungs. Symptoms typically develop many decades after initial exposure to asbestos, leaving an enduring legacy of disease. Vaccine-induced augmentation of immune responses unleashed during checkpoint blockade may provide further clinical benefit in mesothelioma. In this study we explore the HLA class I antigenic landscape (or immunopeptidome) of mesothelioma in patient derived cell line and clinical material (pleural effusion samples).

INSTRUMENT(S): Bruker Daltonics timsTOF series

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung, Mesothelial Cell Of Pleura

DISEASE(S): Malignant Pleural Mesothelioma

SUBMITTER: Kirti Pandey  

LAB HEAD: Anthony Wayne

PROVIDER: PXD054498 | Pride | 2025-05-07

REPOSITORIES: Pride

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Action DRS
25-Aug-23_20230825_KP_UWA_PE_P4724_S1-A1_1_2504.d.zip Other
25-Aug-23_20230825_KP_UWA_PE_P4724_S1-A1_1_2504.mgf Mgf
25-Aug-23_20230825_KP_UWA_PE_P4724_S1-A1_1_2504.mzidentml_1_1_0.xml.gz Mzid
25-Aug-23_20230825_KP_UWA_PE_P4724_S1-A1_1_2504.raw.mgf Mgf
25-Aug-23_20230825_KP_UWA_PE_P6215_S1-A2_1_2505.d.zip Other
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Publications

Multiple Classes of Antigen Contribute to the Antigenic Landscape of Mesothelioma.

Pandey Kirti K   Faridi Pouya P   Ayala Rochelle R   Lee Y C Gary YCG   Rouse Ebony E   Krishna Sanjay S G SSG   Dick Ian I   Redwood Alec A   Robinson Bruce B   Creaney Jenette J   Purcell Anthony W AW  

Molecular & cellular proteomics : MCP 20250205 3

Mesothelioma is an incurable, asbestos-exposure-related cancer that typically affects the lining or pleura of the lungs. Symptoms typically develop many decades after initial asbestos exposure, leaving an enduring legacy of disease. The current disease burden is peaking worldwide and thus there is a massive unmet clinical need for curative therapies. Recently, immune checkpoint blockade-based therapy has been adopted as a first-line of treatment for mesothelioma. Vaccine-induced augmentation of  ...[more]

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