Identification of ASC-interacting proteins

ABSTRACT: To explore the spatiotemporal regulation of ASC speck formation and inflammasome activation, we treated primary WT and Asc–/– bone marrow-derived macrophages (BMDMs) with LPS (500 ng/ml) and ATP (5 mM) to activate NLRP3 inflammasome activation and then performed ASC IP-MS to identify proteins that interacted with ASC. We compared the IP products between WT BMDMs and Asc–/– BMDMs, and found that many proteins specifically interacted with ASC

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Suspension Culture, Bone Marrow, Macrophage

DISEASE(S): Primary Immunodeficiency Disease

SUBMITTER: Xiaopeng Qi  

LAB HEAD: Xiaopeng Qi

PROVIDER: PXD054933 | Pride | 2026-06-29

REPOSITORIES: Pride