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CD8 T cell phosphoproteome LC-MSMS

ABSTRACT: Label-free phosphoproteome measurements of donor-derived CD8 T cells with and without cell cycle blockers.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Primary Cell

SUBMITTER: Rayman Tjokrodirijo

LAB HEAD: Peter van Veelen

PROVIDER: PXD055517 | Pride | 2026-03-09

REPOSITORIES: Pride

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			Action	DRS
	E20202000308.raw	Raw
	E20202000309.raw	Raw
	E20202000310.raw	Raw
	E20202000311.raw	Raw
	E20202000312.raw	Raw

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1 - 5 of 11

Publications

Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling.

van Haften Floortje J FJ van der Sluis Tetje C TC Hepp Hanna S HS Mülling Nils N Nadafi Reza R Sampadi Bharath B van Duikeren Suzanne S Mostert J Shirin JS van der Sterre Rosemarijn R van Veelen Peter A PA Heieis Graham A GA Veerkamp Dominique M B DMB Wesselink Thomas H TH Vleeshouwers Ward W Beijnes Macha M Pardieck Iris N IN van Horssen Eralin L F ELF de Groot Anne F AF van der Ploeg Manon M Kroep Judith R JR de Miranda Noel F C C NFCC van der Zanden Sabina Y SY Neefjes Jacques J Mei Hailiang H Vertegaal Alfred C O ACO Everts Bart B van der Burg Sjoerd H SH Arens Ramon R

Nature immunology 20260119 3

Cell cycle-inhibiting chemotherapeutics are widely used in cancer treatment. Although the primary aim is to block tumor cell proliferation, their clinical efficacy also involves specific effector CD8+ T cells that undergo synchronized proliferation and differentiation. How CD8+ T cells are programmed when these processes are uncoupled, as occurs during cell cycle inhibition, is unclear. Here, we show that activated CD8+ T cells arrested in their cell cycle can st ...[more]

PMID: 41555086

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