Proteomics

Dataset Information

0

Unravelling the Proteomic Landscape of Imipenem Resistance in Pseudomonas aeruginosa: A Comparative Investigation between Clinical and Control Strains

ABSTRACT: The proteomic landscape of Pseudomonas aeruginosa under the influence of Imipenem, a commonly used antibiotic, has been the subject of investigation in this study. Our comparative analysis between the world epidemic clinical strain (6378/09) and the control strain (ATCC 27853)has revealed results highlighting the proteomic changes that occur in response to varying Imipenem concentrations. Utilizing label-free quantification (LFQ) intensity scores, protein-level t-tests, and Gene Ontology (GO) enrichment analysis, we have been able to delve deeper into the molecular mechanisms that underpin Imipenem resistance.

INSTRUMENT(S):

ORGANISM(S): Pseudomonas Aeruginosa Atcc 700888

SUBMITTER: Animesh Sharma  

LAB HEAD: Francesca Di Bartolomeo

PROVIDER: PXD055744 | Pride | 2026-04-13

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
20211207_SINTEF_DDA_sample-A1-1.d.tar Other
20211207_SINTEF_DDA_sample-A1-2.d.tar Other
20211207_SINTEF_DDA_sample-A1-3.d.tar Other
20211207_SINTEF_DDA_sample-A1-4.d.tar Other
20211207_SINTEF_DDA_sample-A1-5.d.tar Other
Items per page:
1 - 5 of 31
altmetric image

Publications

Proteomic landscape of imipenem resistance in <i>Pseudomonas aeruginosa</i>: a comparative investigation between clinical and control strains.

Eidsaa Marius M   Sharma Animesh A   Janasch Markus M   Kuch Alicja A   Skoczyńska Anna A   Di Bartolomeo Francesca F  

Frontiers in cellular and infection microbiology 20251016

The increasing prevalence of antimicrobial resistance (AMR) poses a significant challenge to global health, particularly with bacterial pathogens such as <i>Pseudomonas aeruginosa</i>, a notorious cause of nosocomial infections. This study focuses on the comparative proteomic analysis of an imipenem-resistant strain of <i>P. aeruginosa</i>, a representative of world epidemic clone ST235, and a wildtype control strain, <i>P. aeruginosa</i> ATCC 27853, in response to varying concentrations of imip  ...[more]

Similar Datasets

Proteomics Proteomics analysis of the Enterobacter cloacae response to imipenem
2021-08-10 | PXD013412 | Pride
Proteomics Global proteomic responses of Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium and Staphylococcus aureus to sub-inhibitory concentrations of antibiotics using LC-MS/MS analysis
2025-09-22 | PXD061388 | Pride
Transcriptomics Murine Microglial Gene Expression after Abdominal Sepsis
2016-07-01 | E-MTAB-4180 | biostudies-arrayexpress
Proteomics Nucleoside Analogues are Potent Inducers of Bacterial Mutagenesis
2021-07-15 | PXD025370 | Pride
Transcriptomics Differential expression of E. coli(pBIC-1a) under imipenem exposure
2018-09-15 | E-MTAB-7190 | biostudies-arrayexpress
Transcriptomics Whole genome \"TraDIS-Xpress\" assay to determine gene roles during growth of E. coli in different concentrations of the antibiotics trimethoprim and sulfamethoxazole
2020-10-19 | E-MTAB-9305 | biostudies-arrayexpress
Proteomics Proteomics Analysis of Evolved Escherichia coli Populations from Cyclic Antibiotic Treatment
2020-01-10 | PXD013326 | Pride
Proteomics Exploring the susceptome of methicillin-resistant Staphylococcus aureus to β-Lactams using a multi-omics approach
2025-12-12 | PXD062516 | Pride
Transcriptomics The impact of heat stress on imipenem susceptibility in imipenem resistant NTHi
2019-01-15 | E-MTAB-6237 | biostudies-arrayexpress
Proteomics PCNA regulates metabolism by stabilizing ENO1 and 6PGD
2023-03-10 | PXD028314 | Pride