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Proteomics study in male C57BL6 tibialis anterior and psoas skeletal muscles.

ABSTRACT: This project contains proteomics data obtained from 8 weeks old tibialis anterior and psoas skeletal muscles from c57bl6 and BlaJ male mice.

INSTRUMENT(S): ZenoTOF 7600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle

DISEASE(S): Autosomal Recessive Limb-girdle Muscular Dystrophy Type 2b

SUBMITTER: Aldo Meizoso Huesca

LAB HEAD: Bradley S. Launikonis

PROVIDER: PXD056568 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	DDABLPS2m_1.timeseries.data	Other
	DDABLPS2m_1.wiff	Wiff
	DDABLPS2m_1.wiff.scan	Wiff
	DDABLPS2m_1.wiff2	Wiff
	DDABLPS2m_2.timeseries.data	Other

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Publications

Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression.

Meizoso-Huesca Aldo A Lamboley Cedric R CR Krycer James R JR Hodson Mark P MP Hudson James E JE Launikonis Bradley S BS

Nature communications 20250328 1

Ryanodine receptor 1 Ca2+ leak is a signal in skeletal muscle, but chronic leak can underlie pathology. Here we show that in healthy male mouse, limb-girdle muscle presents higher sympathetic input, elevated ryanodine receptor 1 basal phosphorylation, Ca2+ leak and mitochondrial Ca2+ content compared to distal leg muscles. These regional differences are consistent with heat generation in resting muscle to maintain core temperature. The dysferlin-null mouse develo ...[more]

PMID: 40155594

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