USP13 dictates RAN turnover and vulnerability to ferroptosis in diffused large B cell lymphoma (DLBCL)

ABSTRACT: To identify the substrates of deubiquitinase USP13, we used a protein label-free quantitation technique, which involves mass spectrometry analysis of peptides from protein digests using liquid chromatography, to identify candidate substrates of USP13 that interact with it from co-immunoprecipitation (Co-IP) of HEK293T cells and candidate substrates of USP13 that are upregulated by its overexpression in HEK293T cells, from the data sets of the full protein profile and protein-protein interactions.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Large B-cell Lymphoma

SUBMITTER: Xuan Qiao  

LAB HEAD: Boheng Li

PROVIDER: PXD056804 | Pride | 2025-12-08

REPOSITORIES: Pride