Dataset Information

A High-salt diet induces immune-independent re-differentiation of melanoma, metabolic shut down and cell-cycle arrest

ABSTRACT: A high salt diet (HSD) is known to reduce cancer growth in some models, due to accumulation of sodium in the skin, which enhanced local anti-tumor immunity. Here we show that a HSD inhibits melanoma growth in both skin and lung, independent from sodium accumulation and from immune cells. Melanoma cells from mice on a HSD upregulated the metabolic inhibitor Tuberous sclerosis complex 2 (TSC2), causing metabolic shutdown, despite nutrient availability. Furthermore, Microphthalmia-associated transcription factor (MITF), a crucial regulator of melanoma metabolism and differentiation, was upregulated, resulting in enhanced melanogenesis and cell cycle arrest. Thus, a HSD reversed the dedifferentiation of melanoma tumor cells and promoted their re-differentiation into a “normal”, melanocytic state. These findings suggest the anti-tumor effects of a HSD may be tumor specific and in some cases immune-independent.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skin

SUBMITTER: Christian Münch

LAB HEAD: Christian Münch

PROVIDER: PXD057160 | Pride | 2026-01-02

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20220419_LU_LC2_MAA_CL_Melanoma_Tumor_Cells_Mice_F0.msf	Msf
	20220419_LU_LC2_MAA_CL_Melanoma_Tumor_Cells_Mice_F0.pdResult	Other
	20220419_LU_LC2_MAA_CL_Melanoma_Tumor_Cells_Mice_F01.raw	Raw
	20220419_LU_LC2_MAA_CL_Melanoma_Tumor_Cells_Mice_F02.raw	Raw
	20220419_LU_LC2_MAA_CL_Melanoma_Tumor_Cells_Mice_F03.raw	Raw

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Publications

High-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma.

Lisowski Clivia C Stumpf Natascha E NE Jobin Katarzyna K Klaus Daniela D Eichler Melanie M Baumgart Ann-Kathrin AK Babyak Olena O Meißner Mirjam M Schröder Agnes A Neubert Patrick P Schmitt Vanessa V Michla Marcel M Bozkurt Süleyman S Zurkovic Jelena J Hinze Daniel D Liebing Jana J Eckhardt Matthias M Heuser Christoph C Seep Lea L Heine Annkristin A Becker-Gotot Janine J Thiele Christoph C Münch Christian C Becker Thomas T Jantsch Jonathan J Wilhelm Christoph C Hölzel Michael M Kurts Christian C

Cell death & disease 20251220 1

High salt diet (HSD) is known to reduce cancer growth in some tumor models, which has been attributed to tissue accumulation of sodium that enhances local anti-tumor immunity. Here, we show that a HSD inhibits melanoma growth independent of sodium accumulation and immune cells in skin and lung. Melanoma cells from mice on a HSD upregulated the metabolic inhibitor Tuberous sclerosis complex 2 (TSC2), causing metabolic shutdown despite nutrient availability. Furthermore, Microphthalmia-associated ...[more]

PMID: 41422056

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