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Serum Disease-specific IgG Fc Glycosylation as Potential Biomarkers for Nonproliferative and Proliferative Diabetic Retinopathy Using Mass Spectrometry

ABSTRACT: The patients were enrolled and categorized into three groups according to clinical diagnosis: non-diabetic retinopathy; nonproliferative diabetic retinopathy ; and proliferative diabetic retinopathy. Gel electrophoresis was performed to separate IgG from morning fasting blood samples and polyaniline magnetic nanomaterials (Fe3O4@PANI) were used to enrich IgG N-glycopeptides from tryptic digestion. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI ToF MS) was used to detect the IgG N-glycopeptides.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood

SUBMITTER: Yishuang Mao

LAB HEAD: Zhili Li

PROVIDER: PXD057612 | Pride | 2025-06-16

REPOSITORIES: Pride

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Publications

Serum Disease-Specific IgG Fc Glycosylation as Potential Biomarkers for Nonproliferative and Proliferative Diabetic Retinopathy Using Mass Spectrometry.

Mao Yishuang Y Zhang Jiyun J Zhang Yixin Y Hu Bojie B Hao Yuhua Y Yuan Zhonghao Z Zhao Xufeng X Wang Yusong Y Wei Zhangwanyu Z Yu Weihong W Li Zhili Z

Molecular & cellular proteomics : MCP 20250409 5

This study investigated the potential of serum disease-specific immunoglobulin G (DSIgG) crystallizable fragment (Fc) N-glycosylation as a diagnostic biomarker for the identification of nonproliferative and proliferative diabetic retinopathy (DR). A total of 160 patients were enrolled and categorized into three groups according to clinical diagnosis: non-diabetic retinopathy (NDR, n = 47); nonproliferative diabetic retinopathy (NPDR, n = 51); and proliferative diabetic retinopathy (PDR, n = 62). ...[more]

PMID: 40204274

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