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Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival

ABSTRACT: In this study, we identified the protein disulfide isomerase (PDI) enzymes PDIA1 and PDIA5 as critical mediators of prostate cancer cell growth and survival. Our research demonstrated that these enzymes have a multifaceted role in prostate cancer: they protect cells from oxidative stress, maintain mitochondrial function, and have important functions as regulators of androgen receptor (AR), a critical oncogenic driver. Indeed, targeting PDIA1/PDIA5 causes destabilization of AR protein, and combining PDI inhibitors with AR-targeting drugs boosted antitumor responses. This work positions PDIA1/PDIA5 as viable therapeutic targets.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Sushma Ramesh Rao

LAB HEAD: Luke A.

PROVIDER: PXD057643 | Pride | 2025-10-15

REPOSITORIES: Pride

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			Action	DRS
	PDIAproject-Digest-CCF642-Rep-1_RA8_1_5530.d.zip	Other
	PDIAproject-Digest-CCF642-Rep-2_RB1_1_5518.d.zip	Other
	PDIAproject-Digest-CCF642-Rep-3_RB2_1_5529.d.zip	Other
	PDIAproject-Digest-CCF642-Rep-4_RB3_1_5519.d.zip	Other
	PDIAproject-Digest-CCF642-Rep-5_RB4_1_5522.d.zip	Other

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