Dataset Information

Dysregulated proteases homoeostasis in primary focal segmental glomerulosclerosis

ABSTRACT: Focal segmental glomerulosclerosis (FSGS) represents a pattern of injuries seen in histopathology rather than a distinct disease. Presently, FSGS is categorized into primary, genetic, and secondary types, although these subcategories probably encompass significantly diverse pathogeneses. Here, we performed liquid chromatography mass spectroscopy (LC-MS)-based proteomics analysis on serum samples from patients with pFSGS, and other proteinuric diseases (including secondary FSGS), as well as healthy controls. We aimed to identify plasma profiles, which could distinguish different FSGS subtypes, as well as other renal diseases.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Focal Segmental Glomerulosclerosis

SUBMITTER: Johannes Schmidt

LAB HEAD: Stefan Kalkhof

PROVIDER: PXD058875 | Pride | 2026-04-13

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	MaxQuant_output.zip	Other
	Q1131054AL_20230119134611_20221228_CO_1131JuSc_R01_.raw	Raw
	Q1131055AT_20230119134635_20221228_CO_1131JuSc_R02_.raw	Raw
	Q1131056A3_20230119134700_20221228_CO_1131JuSc_R03_.raw	Raw
	Q1131057AB_20230119134727_20221228_CO_1131JuSc_R04_.raw	Raw

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Publications

Dysregulated Protease Homeostasis Defines Primary FSGS.

Schmidt Johannes J Sopel Nina N Rist Carmen C Ohs Alexandra A Dawid Laura L Simm Stefan S Catanese Lorenzo L Rupprecht Harald H Jobst-Schwan Tilman T Lehmann Jörg J Daniel Christoph C Kalkhof Stefan S Schiffer Mario M Müller-Deile Janina J

Kidney360 20251110 3

<h4>Key points</h4>Serum proteomics reveals reduced serpin family A member 1 (SERPINA1) in primary FSGS, distinguishing it from other proteinuric kidney diseases. Serpina1 knockdown in zebrafish causes proteinuria and edema, supporting its functional relevance in glomerular disease. SERPINA1 may exert compartment-specific functions, and its decrease may permit protease activity to contribute to podocyte injury in primary FSGS.<h4>Background</h4>Primary FSGS (pFSGS) is caused by circulating perme ...[more]

PMID: 41910486

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