Dataset Information

Pancreatic cancer Serpinb9（KD VS NC) proteomics

ABSTRACT: This study investigates the proteomic alterations in pancreatic cancer cells resulting from Serpinb9 knockdown (KD) compared to normal control (NC). Two experimental groups, each consisting of three biological replicates, were analyzed to identify key proteins and pathways associated with Serpinb9's role in pancreatic cancer. Protein identification and quantification were performed using high-resolution mass spectrometry to provide insights into molecular mechanisms underlying its biological function

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Pancreatic Cancer Cell

SUBMITTER: Hanshen Yang

LAB HEAD: Hanshen Yang

PROVIDER: PXD059411 | Pride | 2025-09-01

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	RE323LQ_NC1_Slot2-21_1_12246.d.zip	Other
	RE323LQ_NC2_Slot2-22_1_12247.d.zip	Other
	RE323LQ_NC3_Slot2-23_1_12248.d.zip	Other
	RE323LQ_PI9_KD1_Slot2-27_1_12254.d.zip	Other
	RE323LQ_PI9_KD2_Slot2-28_1_12255.d.zip	Other

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Publications

Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer.

Yang Hanshen H Zhang Xiaozhen X Zhang Sirui S Yang Yanqing Y Chen Yan Y Jiang Yangwei Y Lu Qingsong Q Liu Lingyue L Lao Mengyi M Du Weiran W Sun Kang K He Lihong L Shi Jiatao J Liu Xinyuan X Song Jinyuan J Lu Na N Huang Junming J Huang Jinyan J Zhou Ruhong R Lu Xiongbin X Liang Tingbo T Bai Xueli X

Nature communications 20250822 1

While dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic cancer patients reveals that spermine levels are significantly elevated and correlate with poor prognosis. Using a multi-omics approach, we identify Serpinb9 as a vulnerability in spermine metabolism in pancreatic cancer. Serpinb9, a serine protease inhibitor, ...[more]

PMID: 40846845

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