Dataset Information

Proteomic Profiling of AVF Remodeling in Mice

ABSTRACT: This project investigates proteomic changes in vascular remodeling at post-operative day 7 in male mice subjected to arteriovenous fistula (AVF) creation compared to sham-operated controls. Using bulk sequencing, differentially expressed proteins and enriched pathways will be identified to understand the molecular mechanisms underlying early AVF remodeling. The study aims to uncover key proteins and signaling pathways driving these processes, providing insights into potential therapeutic targets to improve AVF maturation and long-term outcomes.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Vein

SUBMITTER: Luis Gonzalez

LAB HEAD: Alan Dardik

PROVIDER: PXD059538 | Pride | 2025-04-19

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	QEp19-1842_Gonzalez_IVC_1.mzid.gz	Mzid
	QEp19-1842_Gonzalez_IVC_1.mzid_QEp19-1842_Gonzalez_IVC_1.MGF	Mzid
	QEp19-1842_Gonzalez_IVC_1.raw	Raw
	QEp19-1847_Gonzalez_IVC_3.mzid.gz	Mzid
	QEp19-1847_Gonzalez_IVC_3.mzid_QEp19-1847_Gonzalez_IVC_3.MGF	Mzid

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Publications

Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure.

Gonzalez Luis A LA Zhang Weichang W Bai Hualong H Taniguchi Ryosuke R Ramachandra Abhay B AB Jovin Daniel G DG Ohashi Yuichi Y Nguyen Mytien M Thaxton Carly C Yatsula Bogdan B Vazquez-Padron Roberto I RI Humphrey Jay D JD Martin Kathleen A KA Kyriakides Themis R TR Dardik Alan A

American journal of physiology. Heart and circulatory physiology 20250417 6

End-stage kidney disease (ESKD) impacts over 740,000 individuals in the United States, with many patients relying on arteriovenous fistulae (AVF) for hemodialysis due to superior patency and reduced infections. However, AVF patency is reduced by thrombosis and neointimal hyperplasia, yielding a 1-yr patency of only 40%-50%. We hypothesized that tenascin-C (TNC), a regulator of inflammation and immune responses after injury, also regulates venous remodeling during AVF maturation. AVF were created ...[more]

PMID: 40247455

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