Dataset Information

Atlas of lysine propionylation in the human right atrium reveals ALDH6A1-NADH pathway involved in the new-onset atrial fibrillation in aging after coronary artery bypass grafting

ABSTRACT: Lysine propionylation modification (Kpr) plays an important role in the pathogenesis of several cardiovascular diseases, but the role of Kpr in postoperative atrial fibrillation (POAF) is unclear. Here, we established an atlas of proteomics and propionylation proteomics in the atrial appendage tissues from 28 aging CABG patients, exploring the role of Kpr proteins in the occurrence of POAF. The Kpr of ALDH6A1 was most significantly increased on Lys113 (2.25 folds). The activity of ALDH6A1 increased due to higher binding energy of propionylated ALDH6A1 and NAD+, causing an increase in NADH levels in cells and triggering abnormal energy metabolism. Furthermore, the increase in NADH levels triggered the accumulation of reactive oxygen species, which may cause oxidative stress and cardiac electrical remodeling, resulting in the development of AF. This study reveals the important role of ALDH6A1-NADH pathway in POAF, and provides new insights for exploring the pathogenesis of POAF in CABG.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart

SUBMITTER: Hai-Tao Hou

LAB HEAD: Hou HT

PROVIDER: PXD059607 | Pride | 2025-08-11

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	XA02141B2LPPr_AF_1_Slot2-7_1_7257.d.zip	Other
	XA02141B2LPPr_AF_2_Slot2-8_1_7259.d.zip	Other
	XA02141B2LPPr_AF_3_Slot2-9_1_7261.d.zip	Other
	XA02141B2LPPr_AF_4_Slot2-10_1_7263.d.zip	Other
	XA02141B2LPPr_AF_5_Slot2-11_1_7265.d.zip	Other

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Publications

Atlas of lysine propionylation of human right atrium and ALDH6A1-NADH pathway in new-onset atrial fibrillation after coronary surgery.

Zhang Yi Y Chen Huan-Xin HX Hou Hai-Tao HT Liu Ying-Qi YQ Chen Zhuo Z Yang Qin Q He Guo-Wei GW

Communications biology 20250604 1

Lysine propionylation modification (Kpr) plays an important role in the pathogenesis of several cardiovascular diseases, but the role of Kpr in postoperative atrial fibrillation (POAF) is unclear. Here, we established an atlas of proteomics and propionylation proteomics in the atrial appendage tissues from 28 CABG patients, exploring the role of Kpr proteins in the occurrence of POAF. The Kpr of ALDH6A1 was most significantly increased on Lys113 (2.25 folds). The activity of ALDH6A1 increased du ...[more]

PMID: 40467924

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