Dataset Information

Proteomic analysis of C2C12 myoblasts treated with Tunicamycin

ABSTRACT: Label free proteomic analysis of C2C12 myoblasts treated with either Tunicamycin (0.2ug/ml) alone or with PERK AMG44 (2uM) for 8h and followed by 16h recovery.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle Myoblast, Cell Culture

SUBMITTER: Brian McDonagh

LAB HEAD: Brian McDonagh

PROVIDER: PXD059735 | Pride | 2026-04-27

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	120mins_OTIT_FusionMS_Ctrl_1.raw	Raw
	120mins_OTIT_FusionMS_Ctrl_2.raw	Raw
	120mins_OTIT_FusionMS_Ctrl_3.raw	Raw
	120mins_OTIT_FusionMS_Ctrl_4.raw	Raw
	120mins_OTIT_FusionMS_Inhib_TM_1.raw	Raw

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Publications

Adaptive ER stress promotes mitochondrial remodelling and longevity through PERK-dependent MERCS assembly.

Casas-Martinez Jose C JC Xia Qin Q Li Penglin P Borja-Gonzalez Maria M Miranda-Vizuete Antonio A McDermott Emma E Dockery Peter P Quinlan Leo R LR Goljanek-Whysall Katarzyna K Samali Afshin A McDonagh Brian B

Cell death and differentiation 20251101 4

The transfer of information and metabolites between the mitochondria and the endoplasmic reticulum (ER) is mediated by mitochondria-ER contact sites (MERCS), allowing adaptations in response to changes in cellular homeostasis. MERCS are dynamic structures essential for maintaining cell homeostasis through the modulation of calcium transfer, redox signalling, lipid transfer, autophagy and mitochondrial dynamics. Under stress conditions such as ER protein misfolding, the Unfolded Protein Response ...[more]

PMID: 41176528

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