Proteomics

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Proteome analysis of satellite cells from DMD and WT pigs

ABSTRACT: Recent studies on the contribution of satellite cells (SC) to Duchenne muscular dystrophy (DMD) documented altered division capacities and impaired regeneration potential of SC in muscle tissue of DMD patients and animal models. Hence, it is crucial to unravel if SC-intrinsic effects trigger these deficiencies at pre-contractile stages of myogenesis rather than resulting consequently from the pathologic environment. Addressing this, we isolated SC from muscle biopsies of a porcine DMD model for cultivation and characterization.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Primary Cell

SUBMITTER: Jan Bernd Stöckl  

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD059983 | Pride | 2025-06-30

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20221116_satcel_DMD_14_p3.raw Raw
20221116_satcel_DMD_14_p4.raw Raw
20221116_satcel_DMD_14_p6.raw Raw
20221116_satcel_DMD_14_p7.raw Raw
20221116_satcel_DMD_15_p3.raw Raw
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Publications

Multi-Modal Analysis of Satellite Cells Reveals Early Impairments at Pre-Contractile Stages of Myogenesis in Duchenne Muscular Dystrophy.

Franzmeier Sophie S   Chakraborty Shounak S   Mortazavi Armina A   Stöckl Jan B JB   Jiang Jianfei J   Pfarr Nicole N   Sabass Benedikt B   Fröhlich Thomas T   Kaufhold Clara C   Stirm Michael M   Wolf Eckhard E   Schlegel Jürgen J   Matiasek Kaspar K  

Cells 20250613 12

Recent studies on myogenic satellite cells (SCs) in Duchenne muscular dystrophy (DMD) documented altered division capacities and impaired regeneration potential of SCs in DMD patients and animal models. It remains unknown, however, if SC-intrinsic effects trigger these deficiencies at pre-contractile stages of myogenesis rather than resulting from the pathologic environment. In this study, we isolated SCs from a porcine DMD model and age-matched wild-type (WT) piglets for comprehensive analysis.  ...[more]

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