Dataset Information

Proteome analysis of WT, TPC2 knockout and TRPML1 knockout HCC cell lines

ABSTRACT: Our proteome analysis revealed that TPC2 ablation alters tumor metabolism while we did not observe the same effect in the case of TRPML1 knockout.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

SUBMITTER: Jan Bernd Stöckl

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD062988 | Pride | 2026-03-12

REPOSITORIES: Pride

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Publications

Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.

Ouologuem Lina L Kübler Anna A Ouologuem Sarah S Hadzic Amar A Stöckl Jan B JB Siciliano Anna Chiara AC Forciniti Stefania S Nigro Salvatore S Iuele Helena H Onesto Valentina V Nguyen Anny A Matzek Dana D Abrahamian Carla C Grimm Christian C Popper Bastian B Gigli Giuseppe G Del Mercato Loretta L LL Merkel Olivia M OM Fröhlich Thomas T Theurich Sebastian S Bartel Karin K

Frontiers in immunology 20251024

<h4>Introduction</h4>Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. Despite significant progress in systemic and immune-based therapies, many patients develop resistance or fail to respond, highlighting the need for new molecular targets. Lysosomal ion channels have recently emerged as important regulators of cancer biology; however, their involvement in tumour-immune interactions is still poorly unde ...[more]

PMID: 41209002

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			Action	DRS
	B16F10_report.tsv	Tabular
	checksum.txt	Txt
	raw_data_b16f10.zip	Other
	raw_data_hep3b.zip	Other
	report_lina_hep3b.tsv	Tabular