Cholangiocarcinoma Cell of PDHA1 MS

ABSTRACT: The discovery of various lysine acylations raises a question as to whether they are subject to dynamic regulation and, if so, by which enzymes. Since acyltransferases play a crucial role in the succinylation process (acyltransferases are responsible for coupling acyl-CoA to non-protein substrates, possibly aiding lysine acylation as a side reaction). Using immunoprecipitation (IP) and liquid chromatographytandem mass spectrometry (LC-MS/MS), we found the succinyltransferase DLST interacts with PDHA1 and had a succinylation effect.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Ning Zhang  

LAB HEAD: Liu Lianxin

PROVIDER: PXD060056 | Pride | 2025-05-07

REPOSITORIES: Pride