Identification of lactoylation on PHGDH
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Marissa Trujillo
LAB HEAD: James Joseph Galligan
PROVIDER: PXD060533 | Pride | 2026-03-09
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| MT_3411126_100mM.raw | Raw | |||
| MT_3411126_100uM.msf | Msf | |||
| MT_3738088_GLO2_PHGDH_MGO_Top_02.msf | Msf | |||
| MT_3738088_GLO2_PHGDH_MGO_Top_02.raw | Raw | |||
| checksum.txt | Txt |
Items per page: 5 1 - 5 of 5 |
Publications
Glyoxalase 2 Coordinates de Novo Serine Metabolism.
Trujillo Marissa N MN Jennings Erin Q EQ Farrera Dominique O DO Kitamura Naoya N Anderson Colin C CC Gehrke Sarah S Reisz Julie A JA Johannsen Mogens M Roede James R JR D'Alessandro Angelo A Galligan James J JJ
Chembiochem : a European journal of chemical biology 20250304 7
Phosphoglycerate dehydrogenase (PHGDH) is the first enzyme in de novo Ser biosynthesis. Numerous metabolic pathways rely on Ser as a precursor, most notably one-carbon metabolism, glutathione biosynthesis, and de novo nucleotide biosynthesis. To facilitate proliferation, many cancer cells shunt glycolytic flux through this pathway, placing PHGDH as a metabolic liability and feasible therapeutic target for the treatment of cancer. Herein, we demonstrate the post-translational modification (PTM) o ...[more]
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