Dataset Information

Comparative proteomics for investigating the effect of tizoxanide treatment in Erwinia amylovora

ABSTRACT: - Identification of proteins whose expression was affected by tizoxanide in Erwinia amylovora strain TS3128 - Shotgun proteomic analysis was used - Two strains were used with three biological replicates (total 6 samples). LB: DMSO treatment. CCL: tizoxanide treatment

INSTRUMENT(S):

ORGANISM(S): Erwinia Amylovora

TISSUE(S): Cell Culture

SUBMITTER: Sang-Wook Han

LAB HEAD: Sang-Wook Han

PROVIDER: PXD060613 | Pride | 2025-10-20

REPOSITORIES: Pride

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Publications

Tizoxanide associated with anti-virulent activity controls fire blight disease caused by Erwinia amylovora in Malus asiatica.

Kim Yeong Seok YS Kang Eom-Jeong EJ Kim Dohyun D Kim Bomin B Han Jae Woo JW Lee Joon-Ho JH Han Sang-Wook SW Choi Gyung Ja GJ Kim Hun H

Communications biology 20251009 1

Erwinia amylovora is a causative pathogen of fire blight disease, affecting apple, pear, and other rosaceous plants. This study aimed to discover new anti-virulence agents to control this plant bacterial disease by preventing its pathogenesis. To this end, 2485 small molecules were screened for targeting the type III secretion system (T3SS) which is a critical virulence factor in E. amylovora. Our screening identified tizoxanide as a potent inhibitor, significantly reducing the promoter activity ...[more]

PMID: 41068275

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			Action	DRS
	CCL1.msf	Msf
	CCL1.raw	Raw
	CCL2.msf	Msf
	CCL2.raw	Raw
	CCL3.msf	Msf