Profiling of the detergent-insoluble proteome of the cortical brain tissues by TMT-LC/LC-MS/MS

ABSTRACT: Mass spectrometry analysis of insoluble proteome from 5xFAD/Mdk-KO mouse brain. This study examines the insoluble protein fraction, focusing on aggregation-prone proteins including Aβ and its associated proteins. The data reveals significant accumulation of Aβ-correlated proteins and microglial components in the absence of MDK, supporting its protective role against amyloid pathology in Alzheimer's disease.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Disease

SUBMITTER: ya huang  

LAB HEAD: Junmin Peng

PROVIDER: PXD061104 | Pride | 2025-07-16

REPOSITORIES: Pride