Dataset Information

Age-Linked Variations in Adipose Tissue Responses to Nerve Injury in a murine model: Sex-Specific Patterns Over Time

ABSTRACT: Adipose tissue (AT) plays a central role in the metabolic and inflammatory responses to neuropathy. It secretes adipokines, such as leptin and adiponectin, which regulate nerve regeneration and inflammation . Postmenopausal women have a higher prevalence of PN, linked to estrogen depletion, which influences immune and inflammatory pathways. Estrogens promote Schwann cell (SC) activity and reduce oxidative stress, offering neuroprotective benefits . Our proteomic analysis is part of the comprehensive investigation in a mouse model of peripheral nerve injury, utilizing behavioral, imaging, biochemical, molecular, and -omics approaches. Our objective is to elucidate the sex-specific metabolic roles of AT in aging-related neuropathy and pain.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): White Fat Cell, White Adipose Tissue

DISEASE(S): Lesion Of Sciatic Nerve

SUBMITTER: Luisa Pieroni

LAB HEAD: Luisa Pieroni

PROVIDER: PXD061152 | Pride | 2025-11-10

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	1_AdiposoFASP_141216.raw.zip	Raw
	1_AdiposoFASP_211216.raw.zip	Raw
	1_AdiposoFASP_211216_B.raw.zip	Raw
	1_AdiposoFASP_211216_C.raw.zip	Raw
	2_AdiposoFASP_141216.raw.zip	Raw

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Publications

Metabolic resilience governs sex-specific pain recovery during hormonal aging: a multi-omics study of neuropathy in mice.

Marinelli Sara S Rossi Claudia C Pieroni Luisa L Giacovazzo Giacomo G Vacca Valentina V De Angelis Federica F Cicalini Ilaria I Mastrorilli Valentina V Parisi Chiara C Yurtsever Zuleyha Nihan ZN Ciavardelli Domenico D Coccurello Roberto R

Frontiers in pain research (Lausanne, Switzerland) 20251013

<h4>Introduction</h4>Biological aging and sex interact to shape systemic metabolism, yet their role in chronic pain resolution remains unexplored. We hypothesized that metabolic resilience-the ability to flexibly switch fuel sources and maintain energy homeostasis-rules successful recovery from nerve injury in a sex-dependent manner during aging.<h4>Methods</h4>In 12-month-old male and female mice, corresponding to the perimenopausal phase in females and the onset of hormonal decline in both sex ...[more]

PMID: 41158618

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